A master station includes a group of circuits for performing an optimization method. In such a system, the optimization is achieved by adjusting the pull-up resistance and by setting the best possible clock frequency to ensure that data/clock high and low voltage levels are within predetermined specifications. An optimization procedure is performed in a calibration phase invoked by a user or a system whenever a change is introduced to the system, such as addition or deletion of slave stations, a change of data/clock lines, or a change that may affect on the electrical and timing characteristics of the two-wire communication system.