Invention Grant
- Patent Title: PEGylated TNF-α variant proteins
- Patent Title (中): PEG化的TNF-α变体蛋白
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Application No.: US11200444Application Date: 2005-08-08
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Publication No.: US07642340B2Publication Date: 2010-01-05
- Inventor: John R. Desjarlais , Jonathan Zalevsky
- Applicant: John R. Desjarlais , Jonathan Zalevsky
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agency: Morgan Lewis & Bockius LLP
- Agent Robin M. Silva, Esq.; David C. Foster, Esq.
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K38/19 ; C07K14/52
Abstract:
The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method.
Public/Granted literature
- US20070009477A1 Methods for rational PEGylation of proteins Public/Granted day:2007-01-11
Information query
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