The present invention relates to the production of amphiphilic copolymer networks, or co-networks, and to methods for preparing amphiphilic co-networks. Furthermore, the present invention relates to products and/or films made from the amphiphilic co-networks produced in accordance with the synthesis methods of the present invention. Additionally, the present invention relates to crosslinked amphiphilic co-networks comprising at least one hydrophilic segment and at least one hydrophobic segment. In one embodiment, the hydrophilic segments include at least one polyalkyl glycol (e.g., polyethylene glycol (PEG)) and the hydrophobic segments include at least one di-alkenyl and/or di-alkynyl terminated polysiloxane (e.g., polydimethylsiloxane (PDMS)). In another embodiment, the amphiphilic co-networks of the present invention are optically clear and highly oxophilic.