Invention Grant
US07642280B2 Inhibitors of acyl glucosaminyl inositol amidase and methods of use
失效
酰基葡糖胺基肌醇酰胺酶的抑制剂及其使用方法
- Patent Title: Inhibitors of acyl glucosaminyl inositol amidase and methods of use
- Patent Title (中): 酰基葡糖胺基肌醇酰胺酶的抑制剂及其使用方法
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Application No.: US10474138Application Date: 2002-04-08
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Publication No.: US07642280B2Publication Date: 2010-01-05
- Inventor: Robert C. Fahey , Gerald L. Newton , Carole A. Bewley , Gillian Nicholas
- Applicant: Robert C. Fahey , Gerald L. Newton , Carole A. Bewley , Gillian Nicholas
- Applicant Address: US CA Oakland US MD Bethesda
- Assignee: The Regents of the University of California,National Institutes of Health
- Current Assignee: The Regents of the University of California,National Institutes of Health
- Current Assignee Address: US CA Oakland US MD Bethesda
- Agency: DLA Piper LLP (US)
- International Application: PCT/US02/11117 WO 20020408
- International Announcement: WO02/081483 WO 20021017
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A61K31/15 ; C07D223/00 ; C07C259/00
Abstract:
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.
Public/Granted literature
- US20040167331A1 Inhibitors of acyl glucosaminyl inositol amidase and methods of use Public/Granted day:2004-08-26
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