Invention Grant
- Patent Title: Fused heteroaryl derivatives for use as P38 kinase inhibitors
- Patent Title (中): 用作P38激酶抑制剂的稠合杂芳基衍生物
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Application No.: US10522955Application Date: 2003-07-30
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Publication No.: US07642276B2Publication Date: 2010-01-05
- Inventor: Richard Martyn Angell , Ian Robert Baldwin , Paul Bamborough , Nigel Marc Deboeck , Timothy Longstaff , Stephen Swanson
- Applicant: Richard Martyn Angell , Ian Robert Baldwin , Paul Bamborough , Nigel Marc Deboeck , Timothy Longstaff , Stephen Swanson
- Applicant Address: US PA Philadelphia
- Assignee: SmithKline Beecham Corporation
- Current Assignee: SmithKline Beecham Corporation
- Current Assignee Address: US PA Philadelphia
- Agent Dara L. Dinner; Charles M. Kinzig
- Priority: GB0217757.4 20020731
- International Application: PCT/GB03/03316 WO 20030730
- International Announcement: WO2004/010995 WO 20040205
- Main IPC: A61K31/423
- IPC: A61K31/423 ; A61K31/404 ; A61K31/428 ; A61K31/496 ; A61K31/5377 ; A61K31/4025 ; A61K31/341 ; A61K31/381 ; C07D403/04 ; C07D261/20 ; C07D277/62 ; C07D413/04
Abstract:
Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
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