Invention Grant
US07642233B2 Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
失效
通过与α血红蛋白稳定蛋白共表达来增强重组血红蛋白的产生
- Patent Title: Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
- Patent Title (中): 通过与α血红蛋白稳定蛋白共表达来增强重组血红蛋白的产生
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Application No.: US11685986Application Date: 2007-03-14
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Publication No.: US07642233B2Publication Date: 2010-01-05
- Inventor: John S. Olson , Mitchell J. Weiss
- Applicant: John S. Olson , Mitchell J. Weiss
- Applicant Address: US TX Houston US PA Philadelphia
- Assignee: William Marsh Rice University,The Children's Hospital of Philadelphia
- Current Assignee: William Marsh Rice University,The Children's Hospital of Philadelphia
- Current Assignee Address: US TX Houston US PA Philadelphia
- Agency: Baker Botts L.L.P.
- Main IPC: C07K14/00
- IPC: C07K14/00
Abstract:
The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microorganisms, or animal erythroid cells. This intact rHb may then be used as part of a blood substitute product.
Public/Granted literature
- US20070154993A1 Enhancing Recombinant Hemoglobin Production By Co-Expression With Alpha Hemoglobin Stabilizing Protein Public/Granted day:2007-07-05
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