Methods and apparatus for locating small indicia in large images are disclosed herein. An example method includes: identifying an aiming pattern zone that includes a detected or presumed location of an aiming light pattern, wherein an offset between the location and a center of image data varies due to a parallax; determining one or more coordinates of the aiming pattern zone; capturing image data representing an image of an environment appearing within a field of view (FOV) of a scanner including the indicia; encoding the one or more coordinates into a tagline of the image; and providing the image with the tagline to an indicia decoder such that the indicia decoder attempts to decode the indicia from the image data starting in a region of the image data selected based upon the one or more coordinates.