A method for performing resource orchestration for microservices-based 5G applications in a dynamic, heterogenous, multi-tiered compute and network environment is presented. The method includes managing compute requirements and network requirements of a microservices-based application jointly by positioning computing nodes distributed across multiple layers, across edges and at a central cloud, identifying and modeling coupling relationships between compute and network resources for a plurality of microservices, when only application-level requirements are provided, to build coupling functions, solving a multi-objective optimization problem to identify how each of the plurality of microservices are deployed in the dynamic, heterogenous, multi-tiered compute and network environment by employing the coupling functions to jointly optimize resource usage of the compute and network resources across different compute and network slices, and deriving optimal joint network and compute resource allocation and function placement decisions.