A method of establishing an enhanced three-dimensional (3D) model of intracranial angiography is provided and includes: obtaining a bright-blood image group, a black-blood image group and an enhanced black-blood image group; preprocessing image pairs to obtain first bright-blood images and black-blood images; registering the first bright-blood image by taking the first black-blood image as reference to obtain a registered bright-blood image group; eliminating flowing void artifact to obtain an artifact-elimination enhanced black-blood image group; subtracting each image of the artifact-elimination enhanced black-blood image group from corresponding black-blood image to obtain angiography enhanced images; establishing a blood 3D model and a vascular 3D model with blood boundary expansion by using the registered bright-blood image group; establishing an angiography enhanced 3D model by using the angiography enhanced images; obtaining an enhanced 3D model of intracranial angiography based on the blood 3D model, the vascular 3D model and the angiography enhanced 3D model.