An electrophoretic display device, including an electrophoretic display panel and a display driving module, is provided. The display driving module is coupled to the electrophoretic display panel and is used for driving the electrophoretic display panel. The display driving module generates multiple first grayscale images according to multiple color pixel values of multiple color pixels corresponding to multiple colors of a color image. The display driving module captures multiple grayscale values of multiple locations of multiple first sub-pixels of the first grayscale images according to multiple locations of multiple mask sub-pixels corresponding to the colors in a mask image to generate multiple second grayscale images. The display driving module synthesizes the second grayscale images to generate a synthesized image. The display driving module drives the electrophoretic display panel according to the synthesized image.