Methods and systems for selecting routes from among multiple media and/or optimizing transmission across those media are described. A minimum data rate may be determined for transmitting a content item. Based on that minimum data rate, a device may determine whether to transmit the content item via a given medium, select a different medium for transmission, or adjust transmission to compensate for unfavorable network conditions. A device may select a medium based on ranking one or more routes from a content source to a user device. Further, a device may determine a data rate for transmission based on calculating an expected time of transmission that includes time spent performing retransmissions at a given data rate.