Invention Grant
- Patent Title: Linear genome assembly from three dimensional genome structure
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Application No.: US16247502Application Date: 2019-01-14
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Publication No.: US12027236B2Publication Date: 2024-07-02
- Inventor: Erez Aiden , Olga Dudchenko , Eric Lander
- Applicant: THE BROAD INSTITUTE, INC. , BAYLOR COLLEGE OF MEDICINE
- Applicant Address: US MA Cambridge
- Assignee: THE BROAD INSTITUTE, INC.,BAYLOR COLLEGE OF MEDICINE
- Current Assignee: THE BROAD INSTITUTE, INC.,BAYLOR COLLEGE OF MEDICINE
- Current Assignee Address: US MA Cambridge; US TX Houston
- Agency: Johnson, Marcou, Isaacs & Nix, LLC
- Agent F. Brent Nix, Esq.
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G16B30/10 ; G16B30/20 ; G16B40/00 ; G16B45/00 ; G16B50/00

Abstract:
Provided herein includes a method for generating an error-corrected genome assembly for an organism comprising: generating a genomic contact map derived from a DNA proximity ligation assay conducted on one or more samples from the organism or a closely related species; superimposing a reference assembled genome derived from whole genome sequencing of one or more samples from the organism on top of the genomic contact map using computer software; correcting errors in the reference assembled genome through a computer user interface to obtain a corrected assembly file, wherein errors in the reference assembled genome are visualized by observing aberrant contacts in the genomic contact map; and applying the corrected assembly file to the reference assembled genome.
Public/Granted literature
- US20190279740A1 LINEAR GENOME ASSEMBLY FROM THREE DIMENSIONAL GENOME STRUCTURE Public/Granted day:2019-09-12
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