Methods, apparatus, systems, and articles of manufacture are disclosed to improve in-memory multiply and accumulate operations. An example apparatus includes a first multiplexer in a subarray of memory, the first multiplexer to receive first values representative of a column of a lookup table (LUT) including entries to represent products of four-bit numbers and return second values from an intersection of a row and the column of the LUT based on a first element of a first operand; shift and adder logic in the subarray, the shift and adder logic to shift the second values based on at least one of the first element of the first operand or a first element of a second operand; and accumulation storage in the subarray, the accumulation storage to store at least the shifted second values.