Provided herein are methods, systems and computer program products for detecting tampering, comprising a sealing process and a seal verification process. The sealing process comprising analyzing a seal applied to seal an object as a tamper evident element, recording one or more manufacturing defects of the seal identified based on the analysis, each of the one or more manufacturing defects comprising one or more non-reproducible deviations from seal generation instructions used to produce the seal, and generating a signature comprising the one or more manufacturing defects. The seal verification process comprising obtaining the signature, analyzing the seal sealing the object, and determining whether the object is tampered based on a comparison between the analyzed seal and the signature.