Restrictions of usage of non-power-two-partition tree in video compression is described. In an exemplary aspect, a method for video processing includes determining, for a conversion between a video and a bitstream representation of the video, whether non-power-of-two partition trees (NPT-T) partition is enabled or disabled, wherein the NPT-T partition include splitting a first block of the video into multiple smaller sized child blocks of the first block, and width (Wi) and/or height (Hi) of at least one child block is a non-power-of-two integer; determining restrictions associated with usage of the NPT-T partition in response to the determination that the NPT-T partition is allowed; and performing the conversion based on the determinations.