Methods and apparatus to cross configure network resources of software defined data centers are disclosed. Example instructions cause one or more processors to monitor a component of a network for a probe packet sent to the component. The example instructions cause the one or more processors to, in response to detecting the probe packet, determine whether the probe packet includes a unique source media access control (MAC) address that is included in a probe access control list (ACL), the unique source MAC address included in the probe ACL set by a decision engine. The example instructions cause the one or more processors to, in response to determining that the probe packet does not include the unique source MAC address, record probe packet receipt information indicating that the probe packet did not pass through a network port of the component and transmit the probe packet receipt information to the decision engine.