The present disclosure provides systems, apparatus, methods, and computer-readable media that support multi-frame depth-of-field (MF-DOF) for deblurring background regions of interest (ROIs), such as background faces, that may be blurred due to a large aperture size or other characteristics of the camera used to capture the image frame. The processing may include the use of two image frames obtained at two different focus points corresponding to the multiple ROIs in the image frame. The corrected image frame may be determined by deblurring one or more ROIs of the first image frame using an AI-based model and/or local gradient information. The MF-DOF may allow selectively increasing a depth-of-field (DOF) of an image to provide focused capture of multiple regions of interest, without causing a reduction in aperture (and subsequently an amount of light available for photography) or background blur that may be desired for photography.