Systems and methods for Semi-Persistent Sounding Reference Signal (SP SRS) resource activation or deactivation are disclosed. In some embodiments, a method of operation of a wireless device in a cellular communications network comprises receiving, from a network node, a Medium Access Control (MAC) Control Element (CE). The MAC CE comprises an indication of a SP SRS resource set to be activated or deactivated and information that indicates a spatial relation for the SP SRS resource set to be activated or deactivated. In this manner, a MAC CE for SP SRS resource set activation or deactivation is provided in a manner that gives spatial relation information in an efficient and flexible manner.