Disclosed is a high-temperature alloy pressure casting mold for an impeller and a guide vane. The high-temperature alloy pressure casting mold includes a casting main pipe, a lower casting pipe, and forming steel mold assemblies, wherein the plurality of forming steel mold assemblies surround the casting main pipe, the casting main pipe is provided with a pressure device, the bottom of the casting main pipe is connected to a casting gate at the bottom of each forming steel mold assembly by means of the lower casting pipe, and casting is carried out using pressure supplied by the main pipe. Further disclosed is a high-temperature alloy pressure casting process for an impeller and a guide vane using the casting mold.