Invention Grant
- Patent Title: Inhibition of expansion and function of pathogenic age-associated B cells and use for the prevention and treatment of autoimmune disease
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Application No.: US17459213Application Date: 2021-08-27
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Publication No.: US11857563B2Publication Date: 2024-01-02
- Inventor: Alessandra Pernis , Michela Manni
- Applicant: New York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special Surgery
- Applicant Address: US NY New York
- Assignee: NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
- Current Assignee: NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
- Current Assignee Address: US NY New York
- Agency: LEASON ELLIS LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A61K31/7105 ; C07K16/30 ; C12N15/113 ; A61P5/48 ; A61P35/00
Abstract:
This current invention provides methods and agents for preventing and treating autoimmune and lymphoproliferative disease by targeting pathogenic age-associated B cells as well as methods of detecting these pathogenic age-associated B cells as a method of diagnosing and predicting autoimmune disease and other lymphoproliferative and chronic inflammatory disorders.
The current invention also provides targets for drug development and basic research for autoimmune diseases and other lymphoproliferative and chronic inflammatory disorders.
The current invention also provides targets for drug development and basic research for autoimmune diseases and other lymphoproliferative and chronic inflammatory disorders.
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