A design is provided for spatially multiplexing uplink channels. A user equipment (UE) detects that a Physical Uplink Control Channel (PUCCH) and a Sounding Reference Signal (SRS) are to be transmitted simultaneously. The UE decides to spatially multiplex the PUCCH and the SRS for simultaneous transmission via different sets of one or more antennas. The UE determines time and frequency resources for the PUCCH and the SRS to avoid collision of at least a portion of the PUCCH with the SRS. The UE transmits the spatially multiplexed PUCCH and SRS using the determined time and frequency resources.