A vehicle can use an image sensor to both detect objects and determine depth data associated with the environment the vehicle is traversing. The vehicle can capture image data and lidar data using the various sensors. The image data can be provided to a machine-learned model trained to output depth data of an environment. Such models may be trained, for example, by using lidar data and/or three-dimensional map data associated with a region in which training images and/or lidar data were captured as ground truth data. The autonomous vehicle can further process the depth data and generate additional data including localization data, three-dimensional bounding boxes, and relative depth data and use the depth data and/or the additional data to autonomously traverse the environment, provide calibration/validation for vehicle sensors, and the like.