Invention Grant
- Patent Title: Use of an integrated microfluidic chip for analysis of cell motility and prediction and prognosis of patient survival
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Application No.: US15780768Application Date: 2016-12-02
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Publication No.: US11747338B2Publication Date: 2023-09-05
- Inventor: Konstantinos Konstantopoulos , Colin Paul , Alfredo Quinones-Hinojosa , Sagar Ramesh Shah , Alejandro Ruiz-Valls , Christopher Yankaskas , Juan Carlos Martinez-Gutierrez , Bin Sheng Wong
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: BALLARD SPAHR LLP
- International Application: PCT/US2016/064725 2016.12.02
- International Announcement: WO2017/096232A 2017.06.08
- Date entered country: 2018-06-01
- Main IPC: G01N33/574
- IPC: G01N33/574 ; B01L3/00 ; G01N33/50
Abstract:
The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.
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