Invention Grant
- Patent Title: Methods and systems for functional maturation of iPSC and ESC derived cardiomyocytes
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Application No.: US16490302Application Date: 2018-03-03
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Publication No.: US11746328B2Publication Date: 2023-09-05
- Inventor: Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
- Applicant: Agilent Technologies, Inc.
- Applicant Address: US CA Santa Clara
- Assignee: Agilent Technologies, Inc.
- Current Assignee: Agilent Technologies, Inc.
- Current Assignee Address: US CA Santa Clara
- International Application: PCT/US2018/020817 2018.03.03
- International Announcement: WO2018/161063A 2018.09.07
- Date entered country: 2019-08-30
- Main IPC: C12N5/077
- IPC: C12N5/077 ; C12N5/00 ; C12N5/074 ; C12N13/00 ; G01N27/02
Abstract:
Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that induces maturation until the immature cardiomyocytes mature into functionally adult cardiomyocytes.
Public/Granted literature
- US20200071672A1 METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES Public/Granted day:2020-03-05
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