Invention Grant
- Patent Title: Compositions, use, and method for CDK2-PROTACs for cancer therapy and hearing loss
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Application No.: US17488080Application Date: 2021-09-28
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Publication No.: US11744896B2Publication Date: 2023-09-05
- Inventor: Jian Zuo , Santanu Hati , Marisa Laura Zallocchi , Robert Hazlitt , Jaeki Min
- Applicant: Creighton University , ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Tennessee not for profit corporation)
- Applicant Address: US NE Omaha
- Assignee: CREIGHTON UNIVERSITY,ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (TENNESSEE NOT FOR PROFIT CORPORATION)
- Current Assignee: CREIGHTON UNIVERSITY,ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (TENNESSEE NOT FOR PROFIT CORPORATION)
- Current Assignee Address: US NE Omaha; US TN Memphis
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: A61K47/55
- IPC: A61K47/55 ; A61P27/16 ; A61K47/54
Abstract:
Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss.
Public/Granted literature
- US20220096642A1 COMPOSITIONS, USE, AND METHOD FOR CDK2-PROTACS FOR CANCER THERAPY AND HEARING LOSS Public/Granted day:2022-03-31
Information query
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