Proposed is a method of manufacturing a dental composite blank. The method of manufacturing the dental composite blank includes (a) pressurizing a laminate for a composite blank having multiple layers having different colors at a first pressure (P1), (b) pressurizing the laminate for a composite blank, pressurized at the first pressure, at a second pressure (P2), and (c) manufacturing a composite blank by curing the pressurized laminate for a composite blank, in which steps (a) and (b) are each independently performed once or multiple times, and the first pressure (P1) is less than or greater than the second pressure (P2), ultimately making it possible to manufacture a dental composite blank that is similar to a natural tooth and thus exhibits a superior aesthetic appearance and high interlayer bonding strength.