Disclosed are techniques for handling of radio frequency front-end group delays (GDs) for round trip time (RTT) estimation. In an aspect, a network entity determines information indicating a network total GD and a user equipment (UE) determines information indicating a UE total GD. The network entity transmits one or more RTT measurement (RTTM) signals to the UE, each including a RTTM waveform. The UE determines one or more one or more RTT response (RTTR) payloads for one or more RTTR signals, each including a RTTR waveform. The UE transmits the RTTR signal(s) to the network entity. For each RTTR signal, a transmission time of the RTTR waveform and/or the RTTR payload is/are determined based on the UE total GD. The network entity determines a RTT between the UE and the network entity based on the RTTM signal(s), the RTTR signal(s), and the information indicating the network total GD.