The image processing device includes a voxel extractor, a learner, and a predictor. The voxel extractor extracts a target voxel and neighboring voxels adjacent to the target voxel from a 3D image. The learner generates vectors corresponding to the target voxel and the neighboring voxels, respectively, generates vector weights corresponding to each of the vectors, based on the vectors and a parameter group, and adjusts the parameter group, based on an analysis result of the target voxel generated by applying the vector weights to the vectors. The predictor generates vectors corresponding to the target voxel and the neighboring voxels, respectively, generates correlation weights among the vectors by applying a parameter group to the vectors, generates vector weights corresponding to each of the vectors by applying the correlation weights to the vectors, and generates an analysis result of the target voxel by applying the vector weights to the vectors.