A wireless network including user equipment (UE) and base stations is configured to perform position determination with low latency and synchronized to a common time within a wireless network. The UE and base stations are configured to perform positioning measurements at a specific time point or within a window around the time point in a measurement period. The time point may be relative to a timing event within the wireless network, such as the beginning or end of a positioning reference signal window or a specific message in a layer 1 or layer 2 transmission. A location server may be provided with the positioning measurements or a position estimate from the UE and provide the position estimate to an external client within the measurement period.