The invention discloses a bionic human esophagus and stomach digestive system including a bionic stomach assembly and a bionic esophagus assembly. The bionic stomach assembly includes a bionic stomach including a stomach body provided with a pylorus and a cardia, a rolling compression apparatus disposed outside the stomach body for performing rolling compression on the bionic stomach, and a gastric juice tube in fluid communication with the stomach body. The bionic esophagus assembly includes a bionic esophagus in fluid communication with the cardia, a first and second esophagus clamp which are respectively clamped at two ends of the bionic esophagus for controlling the esophagus to be opened or closed, and a vibrator disposed between the first and second esophagus clamps for driving the bionic esophagus to vibrate. In the application, the bionic stomach and esophagus are subject to mechanical compression and vibration, thereby simulating a real stomach digestive system.