Provided is a disassembly and assembly structure of a glasses side cover, including a pair of glasses and at least one side cover. The glasses have a frame and two temples. At least one temple is provided with a chute with an opening adjacent to the pivot portion. The chute forms a first end and a second end along the length direction, and an end of the opening adjacent to the first end is provided with a resisting portion. The at least one side cover has a guide seat and a first plate arranged below the guide seat. The guide seat detachably straddles an outer edge of the opening, and is provided with an operating member received in the chute. The front end of the operating member is provided with a positioning block. When the operating member slides to the first end, the positioning block is embedded between the first end and the resisting portion to be fixed according to the elasticity of the material. When the operating member is pressed, the positioning block is detached from the fixation and slid to the second end such that the side cover can be detached from the temple.