A personal defense device arranged to self-orient and enable accurate aim when gripped by a user is provided. The device has a body including upper and lower regions. The upper region includes a transverse index finger loop, a front portion, a rear portion with a storage cavity for a repellant spray container, a spray opening through the upper region, a thumb support, and a top surface. The top surface is above and perpendicular to the transverse loop, which forms an extended sightline for aiming at a potential target. The lower region includes a grip handle providing multi-finger grip below the index finger transverse loop. The transverse loop, multi-finger grip handle and thumb support self-orient the device in the user's hand, and the top surface sightline enables rapid aiming. The upper region front portion can include a contact feature for defensive contact with an attacker and DNA collection.