In one example, a hygienic fitting assembly is disclosed. The hygienic fitting assembly includes a first fitting member defining an exterior opening, an interior opening, and a passage extending therebetween. The hygienic fitting assembly further includes a second fitting member receivable by the first fitting member with the first and second fitting members configured for removable mechanical attachment with one another along an interface region within the passage. The hygienic fitting assembly further includes a seal formed from a compression controlled and self-lubricating material. The seal is configured to receive an annular feature of one of the first or second fitting members and define sanitary fitting connection therebetween. The sanitary fitting connection is operable to prevent fluid escape toward the interface region during flow of a product between the first and second fitting members.