Invention Grant
- Patent Title: T cell receptor
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Application No.: US16343252Application Date: 2017-10-19
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Publication No.: US11643451B2Publication Date: 2023-05-09
- Inventor: Hans Stauss , Sharyn Thomas , Ben Willcox , Fiyaz Mohammed
- Applicant: UCL Business LTD
- Applicant Address: GB London
- Assignee: UCL Business LTD
- Current Assignee: UCL Business LTD
- Current Assignee Address: GB London
- Agency: Cooley LLP
- Priority: GB 17714 2016.10.19
- International Application: PCT/GB2017/053167 2017.10.19
- International Announcement: WO2018/073595A 2018.04.26
- Date entered country: 2019-04-18
- Main IPC: C07K14/725
- IPC: C07K14/725 ; C07K1/00 ; A61K38/00

Abstract:
TCR The present invention relates to an engineered T cell receptor (TCR). In particular, the present invention relates to methods for expression of a TCR when expressed as an exogenous TCR, to methods for selecting a TCR with high cell surface expression when expressed as an exogenous TCR and to methods for identifying residues which contribute to the cell surface expression level of a TCR. The present invention also relates to an engineered TCR which has a high level of cell surface expression when expressed as an exogenous TCR compared to the corresponding germline TCR sequence.
Public/Granted literature
- US20190338012A1 T CELL RECEPTOR Public/Granted day:2019-11-07
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