Invention Grant
- Patent Title: Tandem repeat cancer-targeting peptides for molecular conjugation or engineering and uses thereof in cancer theranostics
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Application No.: US17173917Application Date: 2021-02-11
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Publication No.: US11643437B2Publication Date: 2023-05-09
- Inventor: John Yu , Alice Yu , Sheng-Hung Wang
- Applicant: Chang Gung Memorial Hospital
- Applicant Address: TW Taoyuan
- Assignee: Chang Gung Memorial Hospital
- Current Assignee: Chang Gung Memorial Hospital
- Current Assignee Address: TW Taoyuan
- Agency: Cesari & McKenna, LLP
- Main IPC: C07K7/06
- IPC: C07K7/06 ; A61K38/08 ; A61K47/69 ; A61K47/60 ; C07K16/32 ; A61K51/08 ; C07K7/08 ; A61K38/10 ; A61K39/395 ; A61P35/00 ; A61K31/353

Abstract:
An isolated cancer-targeting peptide that includes at least two copies of the amino acid sequence PFLP (SEQ ID NO: 1) or PFLF (SEQ ID NO: 2). Also disclosed is a pharmaceutical composition for treating cancer. The composition contains the isolated cancer-targeting peptide and an anti-cancer agent. Further disclosed is a bispecific anti-cancer antibody that includes the isolated cancer-targeting peptide and an antigen-binding peptide that stimulates T cell activity. Methods are provided for treating cancer by administering the pharmaceutical composition or the bispecific anti-cancer antibody. Further provided is a method for diagnosing cancer by administering a radionuclide-labeled cancer-targeting peptide to an individual and imaging a location of the radionuclide.
Public/Granted literature
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