An additive manufacturing system has an extruder and a printhead module with a conveyor for moving between the extruder and the printhead module. The extruder is operated to form a support layer having microneedle protrusions. The conveyor moves the support layer having the microneedle protrusions to a position opposite the printhead module for sharpening of the microneedle protrusions and the application of a medicament to the sharpened microneedle protrusions.