Invention Grant
- Patent Title: Enhanced chemiluminescent enzyme-linked immunosorbent assay for detection of antibodies against Babesia microti
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Application No.: US16761034Application Date: 2018-11-01
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Publication No.: US11639930B2Publication Date: 2023-05-02
- Inventor: Sanjai Kumar , Nitin Verma , Ankit Puri , Peter J. Krause
- Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services , Yale University
- Applicant Address: US MD Silver Spring; US CT New Haven
- Assignee: The U.S.A., as represented by the Secretary, Department of Health and Human Services,Yale University
- Current Assignee: The U.S.A., as represented by the Secretary, Department of Health and Human Services,Yale University
- Current Assignee Address: US MD Silver Spring; US CT New Haven
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2018/058723 WO 20181101
- International Announcement: WO2019/089936 WO 20190509
- Main IPC: C07K14/44
- IPC: C07K14/44 ; G01N33/543 ; C12N15/10 ; G01N33/569
Abstract:
Identification of immunodominant Babesia microti antigens using genome-wide immunoscreening is described. Candidate antigens were screened against sera from patients with clinical babesiosis. Also described are diagnostic assays with high sensitivity and specificity for detecting B. microti-specific antibodies in patient samples using the identified immunodominant antigens.
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