Invention Grant
- Patent Title: Bispecific antibodies specific for T-cell activating antigens and a tumor antigen and methods of use
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Application No.: US14269950Application Date: 2014-05-05
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Publication No.: US11639397B2Publication Date: 2023-05-02
- Inventor: Peter Bruenker , Tanja Fauti , Christiane Neumann , Christian Klein , Pablo Umana
- Applicant: Roche Glycart AG
- Applicant Address: CH Schlieren
- Assignee: Roche Glycart AG
- Current Assignee: Roche Glycart AG
- Current Assignee Address: CH Schlieren
- Agency: Clark & Elbing LLP
- Agent Karen L. Elbing
- Priority: EP1178410 20110823
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/30 ; C07K16/28

Abstract:
The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Public/Granted literature
- US20150274845A1 BISPECIFIC ANTIBODIES SPECIFIC FOR T-CELL ACTIVATING ANTIGENS AND A TUMOR ANTIGEN AND METHODS OF USE Public/Granted day:2015-10-01
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