Disclosed are a pre-drive module of an analog-to-digital converter and an analog-to-digital conversion device. The pre-drive module includes a sampling capacitor; a controller configured to output a reset control signal, a pre-sampling control signal, and a sampling control signal according to a preset timing sequence; a reset module configured to reset the sampling capacitor upon receiving the reset control signal; a first auxiliary drive circuit configured to amplify an input analog signal and output to the sampling capacitor for sampling upon receiving the sample control signal; and a second auxiliary drive circuit. The controller is configured to output the pre-sampling control signal before outputting the sampling control signal, control the second auxiliary drive circuit to amplify the input analog signal, and output to the sampling capacitor for pre-sampling, and when a charging voltage of the sampling capacitor during pre-sampling reaches a preset voltage value, output the sampling control signal.