A display driver includes image processing circuitry and driver circuitry. The image processing circuitry is configured to process first image data for pixels of a display panel comprising a first region and a second region to generate output voltage data. The first region and the second region have different pixel layouts. The driver circuitry is configured to update the pixels based on the output voltage data. Processing the first image data comprises IR-drop compensation based on first luminances of the pixels, each of the first luminances being determined based on the first image data and whether a corresponding pixel of the pixels is located in the first region.