In an aspect, a system for generating lifestyle change recommendations based on biological extractions includes a computing device designed and configured for receiving a biological extraction pertaining to a user generating, using a first machine-learning process, a plurality of lifestyle intervention combinations as a function of the biological extraction, assigning, to each lifestyle intervention combination of the plurality of lifestyle intervention combinations, a degree of projected user adherence to the lifestyle intervention combination, wherein assigning further comprises performing a second machine learning process, and selecting, from the plurality of lifestyle intervention combinations, a lifestyle intervention combination as a function of the degree of projected user adherence of the selected lifestyle intervention combination.