A system and method that provides customized graphical user interfaces on mobile devices based on user inputs. An exemplary method includes detecting a computing device remotely connected to a remote server over a network and having an active session of a software application running on the remote server. Moreover, the method further includes identifying and selecting one or more hotkey buttons based on the detected software application, transmitting the one or more hotkey buttons to the computing device to be displayed in a customized interface while the software application is active, detecting an activation of the one or more hotkey buttons displayed on the computing device, and executing, by the remote server, an operation for the active software application in response to the activation of the one or more hotkey button by the user.