Provided is a tube pump system which includes: a pair of roller units which are rotated around an axis line from a closing position to a releasing position; a pair of drive units which are configured to respectively rotate the pair of roller units; a control unit which is configured to control each of the pair of drive units; and a pressure sensor which is configured to detect a pressure of a liquid in a pipe connected to the other end of the tube, wherein the control unit controls a first rotation angle when the first roller unit passes through the closing position and a second rotation angle when the second roller unit passes through the releasing position such that fluctuation of the pressure of the liquid when the pair of roller units are rotated through at least one revolution falls within a predetermined value.