Invention Grant
- Patent Title: Human kynureninase enzyme variants having improved pharmacological properties
-
Application No.: US16081492Application Date: 2017-03-02
-
Publication No.: US11542486B2Publication Date: 2023-01-03
- Inventor: George Georgiou , Everett Stone , John Blazeck
- Applicant: Board of Regents, the University of Texas System
- Applicant Address: US TX Austin
- Assignee: Board of Regents, the University of Texas System
- Current Assignee: Board of Regents, the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2017/020355 WO 20170302
- International Announcement: WO2017/151860 WO 20170908
- Main IPC: C12N9/14
- IPC: C12N9/14 ; A61K47/60 ; A61P35/00 ; A61K35/17 ; A61K38/46 ; A61K39/395 ; C12N9/96
Abstract:
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
Public/Granted literature
- US20210207110A1 HUMAN KYNURENINASE ENZYME VARIANTS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES Public/Granted day:2021-07-08
Information query
