Invention Grant
- Patent Title: Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes
-
Application No.: US16973896Application Date: 2019-06-13
-
Publication No.: US11542227B2Publication Date: 2023-01-03
- Inventor: Susan E. Bergeson , Peter Syapin , Ted W. Reid , Mayank Shashtri , Phat Tran
- Applicant: Texas Tech University System
- Applicant Address: US TX Lubbock
- Assignee: Texas Tech University System
- Current Assignee: Texas Tech University System
- Current Assignee Address: US TX Lubbock
- Agency: Chalker Flores, LLP
- Agent Edwin S. Flores; Daniel J. Chalker
- International Application: PCT/US2019/036892 WO 20190613
- International Announcement: WO2019/241466 WO 20191219
- Main IPC: A61K31/65
- IPC: A61K31/65 ; C07C237/26 ; A61B5/00 ; C07D317/72
Abstract:
A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.
Information query
