An embodiment closure module frame structure of a vehicle includes a platform extending from a front to a rear of the vehicle to form an outer floor surface; a first and a second cabin frame provided on the platform such that the first and the second cabin frame are spaced apart from each other while facing each other; at least one middle connection part placed between the first and the second cabin frame; load path units that are in contact with the first and the second cabin frame, and are connected to opposite sides starting from the middle connection part; and a cabin unit inserted between the load path units to be fastened to the first and the second cabin frame.