Invention Grant
- Patent Title: Multi-drug antibody drug conjugates
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Application No.: US16463541Application Date: 2017-12-14
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Publication No.: US11541128B2Publication Date: 2023-01-03
- Inventor: Matthew R. Levengood
- Applicant: Seagen Inc.
- Applicant Address: US WA Bothell
- Assignee: Seagen Inc.
- Current Assignee: Seagen Inc.
- Current Assignee Address: US WA Bothell
- Agency: Morrison & Foerster LLP
- Priority: JPJP2017-115832 20170613
- International Application: PCT/US2017/066504 WO 20171214
- International Announcement: WO2018/112253 WO 20180621
- Main IPC: A61K47/61
- IPC: A61K47/61 ; A61K31/4745 ; A61K31/704 ; A61K31/496 ; A61K47/68 ; A61K47/60
Abstract:
The present disclosure provides, inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units, that are constructed in a site-specific matter via ‘orthogonal’ deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure.
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