A system of monitoring depression in a user, uses a computer system. The system initially calibrates, to determine baseline information about the user for each of a plurality of different categories of action of the user and continues learning about the user to make minor adjustments to prescribed behaviors and therapies. The categories can include sleep, diet, screen time, exercise, social interaction, medication compliance, and academic performance. The computer system uses the baseline information to determine user behavior, for each of the different categories that is correlated with likely behavior associated with depression. After initially calibrating, the computer system operates to monitor each of said different categories of action of the user and compares the monitored categories with the baseline information to determine whether the user is complying by acting within specified parameters within each category. The system can provide positive reinforcement and alerts.