A data compression device and a compression method are provided. The data compression device includes a quantization table processing unit and a quantization unit. The quantization table processing unit determines a target quantization table in which a quantization coefficient satisfies a data distortion rate and a compression ratio of a preset condition according to a target compression ratio. By constructing different quantization tables for different data, a distortion rate is greatly reduced based on satisfying a compression ratio, and issues that the distortion rate and the compression ratio cannot be simultaneously satisfied in the prior art are alleviated.