Discussed herein are devices, systems, and methods for autonomous, dynamic course of action (COA) generation and management. A method can include issuing a communication to one or more assets indicating operations of a first COA to be performed, receiving, by an intelligence, surveillance, and reconnaissance (ISR) device, data indicating an unexpected event, not accounted for in the first COA, has occurred, in response to the data indicating the unexpected event, identifying a second COA or a portion of a second COA that satisfies a mission of the first COA and accounts for the unexpected event, and issuing a second communication to the one or more assets indicating one or more operations of the second COA to be performed.